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Chemically-modified siRNA

The biggest challenges of RNAi technology are the stability of siRNA and its delivery efficiency. Chemical modifications such as 2' O-Methyl RNA and  2' Fluoro RNA  will increase siRNAs' stability in serum and other medium, while minimize off-target effects. Also, some modification, such as cholesterol modification, will increase tranfection efficiency.

1.  Chemical Modification available

2' O-Methyl phosphoramidites
2'-O-Me-rA, 2'-O-Me-rC, 2'-O-Me-rG, 2'-O-Me-rU
Increase stability, minimize off-target effect: Prolong RNAi effect (Long-lasting siRNA)
 
2' Fluoro phosphoramidites 
2'-FluoC, 2'-FluoU
5' modifications
5'-Amino, 5'-Biotin, 5'-Cholesterol, 5'-Phophorylation and 5'-Thio
For specific applications  (Special Application siRNA)
 
3' modification
3'-Amino
 
2.  Comparable table of chemically-modified and standard siRNAs
 Critical challenges Standard siRNA  Chemically-modified siRNA
 siRNA degradation The non-modified standard siRNA is easy to  be degraded in cell culture process. Although it is effective in most in vitro experiments, its life expectancy is shorter in cell culture. The chemically-modified siRNA not only increases its life expectancy in serum and cell culture, but also strengthens its in vitro application capability
 Time of effect            Relative short time effect, under normal circumstances for approximately one week. The chemically-modified siRNA has long time effect, its effective time is twice as that of the standard siRNA
 In vivo activity The standard siRNA has poor stability, usually is not applicable to vivo experiments The chemically-modified siRNA has strong stability in vivo

 



Product Image Catalog# Product Description Price
Chemically-modified siRNA (2 OD) CMSI01-02

Chemically-modified siRNA (2 OD)

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Excellent results can be obtained as follows: Highly efficient gene knockout high specificity - for purpose...
$129.00     Add:

Chemically-modified siRNA (5 OD) CMSI01-05

Chemically-modified siRNA (5 OD)

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Excellent results can be obtained as follows: Highly efficient gene knockout high specificity - for purpose...
$185.00     Add:

Chemically-modified siRNA (10 OD) CMSI01-10

Chemically-modified siRNA (10 OD)

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Excellent results can be obtained as follows: Highly efficient gene knockout high specificity - for purpose...
$335.00     Add:

Chemically-modified siRNA (25 OD) CMSI01-25

Chemically-modified siRNA (25 OD)

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Excellent results can be obtained as follows: Highly efficient gene knockout high specificity - for purpose...
$685.00     Add:

Chemically-modified siRNA (50 OD) CMSI01-50

Chemically-modified siRNA (50 OD)

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Excellent results can be obtained as follows: Highly efficient gene knockout high specificity - for purpose...
$1,250.00     Add:

Chemically-modified siRNA (100 OD) CMSI01-100

Chemically-modified siRNA (100 OD)

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Excellent results can be obtained as follows: Highly efficient gene knockout high specificity - for purpose...
$2,125.00     Add:

Chemically-modified siRNA (250 OD) CMSI01-250

Chemically-modified siRNA (250 OD)

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Excellent results can be obtained as follows: Highly efficient gene knockout high specificity - for purpose...
$3,999.00     Add:


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